Metabolically inert perfluorinated fatty acids directly activate uncoupling protein 1 in brown-fat mitochondria

The metabolically inert perfluorinated fatty acids perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) can display fatty acid-like activity in biological systems. The uncoupling protein 1 (UCP1) in brown adipose tissue is physiologically (re)activated by fatty acids, including octanoate....

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Bibliografiske detaljer
Udgivet i:Arch Toxicol
Main Authors: Shabalina, Irina G., Kalinovich, Anastasia V., Cannon, Barbara, Nedergaard, Jan
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2015
Fag:
Molecular Toxicology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830884/
https://ncbi.nlm.nih.gov/pubmed/26041126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-015-1535-4
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