Quantification of Low-Level Drug Effects Using Real-Time, in vitro Measurement of Oxygen Consumption Rate

There is a general need to detect toxic effects of drugs during preclinical screening. We propose that increased sensitivity of xenobiotics toxicity combined with improved in vitro physiological recapitulation will more accurately assess potentially toxic perturbations of cellular biochemistry that...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Neal, Adam, Rountree, Austin M., Philips, Craig W., Kavanagh, Terrance J., Williams, Dominic P., Newham, Peter, Khalil, Gamal, Cook, Daniel L., Sweet, Ian R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Oxygen Consumption Analysis to Assess Drug Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830255/
https://ncbi.nlm.nih.gov/pubmed/26396153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv208
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