The Mechanism of the AppA(BLUF) Photocycle Probed by Site-Specific Incorporation of Fluorotyrosine Residues: The Effect of the Y21 pK(a) on the Forward and Reverse Ground State Reactions

The transcriptional antirepressor AppA is a blue light using flavin (BLUF) photoreceptor that releases the transcriptional repressor PpsR upon photoexcitation. Light activation of AppA involves changes in a hydrogen bonding network that surrounds the flavin chromophore on the nanosecond timescale, w...

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Publicado no:J Am Chem Soc
Main Authors: Gil, Agnieszka, Haigney, Allison, Laptenok, Sergey P., Brust, Richard, Lukacs, Andras, Iuliano, James, Jeng, Jessica, Melief, Eduard, Zhao, Rui-Kun, Yoon, EunBin, Clark, Ian, Towrie, Michael, Greetham, Gregory M., Ng, Annabelle, Truglio, James, French, Jarrod, Meech, Stephen R., Tonge, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830125/
https://ncbi.nlm.nih.gov/pubmed/26708408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b11115
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