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Islands of spatially discordant APD alternans underlie arrhythmogenesis by promoting electrotonic dyssynchrony in models of fibrotic rat ventricular myocardium

Fibrosis and altered gap junctional coupling are key features of ventricular remodelling and are associated with abnormal electrical impulse generation and propagation. Such abnormalities predispose to reentrant electrical activity in the heart. In the absence of tissue heterogeneity, high-frequency...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Majumder, Rupamanjari, Engels, Marc C., de Vries, Antoine A. F., Panfilov, Alexander V., Pijnappels, Daniël A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829862/
https://ncbi.nlm.nih.gov/pubmed/27072041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24334
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