Mitochondrial Translocation of High Mobility Group Box 1 Facilitates LIM Kinase 2-Mediated Programmed Necrotic Neuronal Death

High mobility group box 1 (HMGB1) acts a signaling molecule regulating a wide range of inflammatory responses in extracellular space. HMGB1 also stabilizes nucleosomal structure and facilitates gene transcription. Under pathophysiological conditions, nuclear HMGB1 is immediately transported to the c...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Cell Neurosci
Egile Nagusiak: Hyun, Hye-Won, Ko, Ah-Reum, Kang, Tae-Cheon
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2016
Gaiak:
Neuroscience
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829584/
https://ncbi.nlm.nih.gov/pubmed/27147971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2016.00099
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