Impact of a cis-associated gene expression SNP in 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance

SUMMARY: Bipolar disorder (BPD) is a highly heritable polygenic disorder. Recent enrichment analyses suggest that there may be true risk variants for BPD among the expression quantitative trait loci (eQTL) in the brain. AIMS: We sought to assess the impact of eQTL variants on BPD risk by combining d...

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Udgivet i:Br J Psychiatry
Main Authors: Li, Ming, Luo, Xiong-jian, Landén, Mikael, Bergen, Sarah E., Hultman, Christina M., Li, Xiao, Zhang, Wen, Yao, Yong-Gang, Zhang, Chen, Liu, Jiewei, Mattheisen, Manuel, Cichon, Sven, Mühleisen, Thomas W., Degenhardt, Franziska A., Nöthen, Markus M., Schulze, Thomas G., Grigoroiu-Serbanescu, Maria, Li, Hao, Fuller, Chris K., Chen, Chunhui, Dong, Qi, Chen, Chuansheng, Jamain, Stéphane, Leboyer, Marion, Bellivier, Frank, Etain, Bruno, Kahn, Jean-Pierre, Henry, Chantal, Preisig, Martin, Kutalik, Zoltán, Castelao, Enrique, Wright, Adam, Mitchell, Philip B., Fullerton, Janice M., Schofield, Peter R., Montgomery, Grant W., Medland, Sarah E., Gordon, Scott D., Martin, Nicholas G., Rietschel, Marcella, Liu, Chunyu, Kleinman, Joel E., Hyde, Thomas M., Weinberger, Daniel R., Su, Bing
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829352/
https://ncbi.nlm.nih.gov/pubmed/26338991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1192/bjp.bp.114.156976
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