Genetic Diversity in the Major Capsid L1 Protein of HPV-16 and HPV-18 in the Netherlands

OBJECTIVES: Intratypic molecular variants of human papillomavirus (HPV) type-16 and -18 exist. In the Netherlands, a bivalent vaccine, composed of recombinant L1 proteins from HPV-16 and -18, is used to prevent cervical cancer since 2009. Long-term vaccination could lead to changes in HPV-16 and -18...

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Publicado en:PLoS One
Autores principales: King, Audrey J., Sonsma, Jan A., Vriend, Henrike J., van der Sande, Marianne A. B., Feltkamp, Mariet C., Boot, Hein J., Koopmans, Marion P. G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829201/
https://ncbi.nlm.nih.gov/pubmed/27070907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152782
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