Monocyte-derived macrophages exhibit distinct and more restricted HIV-1 integration site repertoire than CD4(+) T cells

The host genetic landscape surrounding integrated HIV-1 has an impact on the fate of the provirus. Studies analysing HIV-1 integration sites in macrophages are scarce. We studied HIV-1 integration site patterns in monocyte-derived macrophages (MDMs) and activated CD4(+) T cells derived from seven an...

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Publicado no:Sci Rep
Main Authors: Kok, Yik Lim, Vongrad, Valentina, Shilaih, Mohaned, Di Giallonardo, Francesca, Kuster, Herbert, Kouyos, Roger, Günthard, Huldrych F., Metzner, Karin J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828718/
https://ncbi.nlm.nih.gov/pubmed/27067385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24157
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