Generation of Novel Traj18-Deficient Mice Lacking Vα14 Natural Killer T Cells with an Undisturbed T Cell Receptor α-Chain Repertoire

Invariant Vα14 natural killer T (NKT) cells, characterized by the expression of a single invariant T cell receptor (TCR) α chain encoded by rearranged Trav11 (Vα14)-Traj18 (Jα18) gene segments in mice, and TRAV10 (Vα24)-TRAJ18 (Jα18) in humans, mediate adjuvant effects to activate various effector c...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Dashtsoodol, Nyambayar, Shigeura, Tomokuni, Ozawa, Ritsuko, Harada, Michishige, Kojo, Satoshi, Watanabe, Takashi, Koseki, Haruhiko, Nakayama, Manabu, Ohara, Osamu, Taniguchi, Masaru
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4827811/
https://ncbi.nlm.nih.gov/pubmed/27064277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153347
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