Poly(ADP-Ribose) Polymerase-1 Regulates the Progression of Autoimmune Nephritis in Males by Inducing Necrotic Cell Death and Modulating Inflammation()

Necrotic lesions and necrotic cell death characterize severe autoimmune nephritides, and contribute to local inflammation and to progression of the disease. Poly(ADP-ribose) polymerase-1 (PARP-1), a DNA repair enzyme, is involved in the induction of necrosis and is a key player in the acute and chro...

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Udgivet i:J Immunol
Main Authors: Jog, Neelakshi R., Dinnall, Joudy-Ann, Gallucci, Stefania, Madaio, Michael P., Caricchio, Roberto
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4827346/
https://ncbi.nlm.nih.gov/pubmed/19454727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803565
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