MRI-based brain atrophy rates in ADNI phase 2: acceleration and enrichment considerations for clinical trials

The goal of this work was to assess statistical power to detect treatment effects in Alzheimer’s disease (AD) clinical trials using magnetic resonance imaging (MRI)–derived brain biomarkers. We used unbiased tensor-based morphometry (TBM) to analyze n = 5,738 scans, from Alzheimer’s Disease Neuroima...

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Dettagli Bibliografici
Pubblicato in:Neurobiol Aging
Autori principali: Hua, Xue, Ching, Christopher R.K., Mezher, Adam, Gutman, Boris A., Hibar, Derrek P., Bhatt, Priya, Leow, Alex D., Jack, Clifford R., Bernstein, Matt A., Weiner, Michael W., Thompson, Paul M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4827255/
https://ncbi.nlm.nih.gov/pubmed/26545631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2015.09.018
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