miR-29b and miR-198 overexpression in CD8(+) T cells of renal cell carcinoma patients down-modulates JAK3 and MCL-1 leading to immune dysfunction

BACKGROUND: Mammalian microRNAs (miR) regulate the expression of genes relevant for the development of adaptive and innate immunity against cancer. Since T cell dysfunction has previously been reported in patients with renal cell carcinoma (RCC; clear cell type), we aimed to analyze these immune cel...

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Publicado en:J Transl Med
Autores principales: Gigante, Margherita, Pontrelli, Paola, Herr, Wolfgang, Gigante, Maddalena, D’Avenia, Morena, Zaza, Gianluigi, Cavalcanti, Elisabetta, Accetturo, Matteo, Lucarelli, Giuseppe, Carrieri, Giuseppe, Battaglia, Michele, Storkus, Walter J., Gesualdo, Loreto, Ranieri, Elena
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4827202/
https://ncbi.nlm.nih.gov/pubmed/27063186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0841-9
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