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Mincle-mediated anti-inflammatory IL-10 response counter-regulates IL-12 in vitro

The role of macrophage-inducible C-type lectin (Mincle) in anti-inflammatory responses has not yet been fully characterized. Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion....

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Detalhes bibliográficos
Publicado no:Innate Immun
Main Authors: Patin, Emmanuel C, Willcocks, Sam, Orr, Selinda, Ward, Theresa H, Lang, Roland, Schaible, Ulrich E
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826952/
https://ncbi.nlm.nih.gov/pubmed/26939595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1753425916636671
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