IL-25 and CD4(+)T(H)2 cells enhance ILC2-derived IL-13 production that promotes IgE-mediated experimental food allergy

BACKGROUND: Food-mediated allergic reactions have emerged as a major health problem. The underlying mechanisms that promote uncontrolled type-2 immune response to dietary allergens in the gastrointestinal tract remain elusive. OBJECTIVE: We investigated whether altering IL-25 signaling enhances or a...

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Vydáno v:J Allergy Clin Immunol
Hlavní autoři: Lee, Jee-Boong, Chen, Chun-Yu, Liu, Bo, Mugge, Luke, Angkasekwinai, Pornpimon, Facchinetti, Valeria, Dong, Chen, Liu, Yong-Jun, Rothenberg, Marc E., Hogan, Simon P., Finkelman, Fred D., Wang, Yui-Hsi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826796/
https://ncbi.nlm.nih.gov/pubmed/26560039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.09.019
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