Methylation of insulin DNA in response to proinflammatory cytokines during the progression of autoimmune diabetes in NOD mice

AIMS/HYPOTHESIS: Type 1 diabetes is caused by the immunological destruction of pancreatic beta cells. Preclinical and clinical data indicate that there are changes in beta cell function at different stages of the disease, but the fate of beta cells has not been closely studied. We studied how immune...

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Foilsithe in:Diabetologia
Main Authors: Rui, Jinxiu, Deng, Songyan, Lebastchi, Jasmin, Clark, Pamela L., Usmani-Brown, Sahar, Herold, Kevan C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826795/
https://ncbi.nlm.nih.gov/pubmed/26910463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-016-3897-4
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