Genetic deletion of osteopontin in TRAMP mice skews prostate carcinogenesis from adenocarcinoma to aggressive human-like neuroendocrine cancers

Osteopontin (OPN) is a secreted glycoprotein, that belongs to the non-structural extracellular matrix (ECM), and its over expression in human prostate cancer has been associated with disease progression, androgen independence and metastatic ability. Nevertheless, the pathophysiology of OPN in prosta...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Mauri, Giorgio, Jachetti, Elena, Comuzzi, Barbara, Dugo, Matteo, Arioli, Ivano, Miotti, Silvia, Sangaletti, Sabina, Di Carlo, Emma, Tripodo, Claudio, Colombo, Mario P.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2015
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826179/
https://ncbi.nlm.nih.gov/pubmed/26700622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6678
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires