MEK inhibitor GSK1120212-mediated radiosensitization of pancreatic cancer cells involves inhibition of DNA double-strand break repair pathways

Purpose: Over 90% of pancreatic adenocarcinoma PC express oncogenic mutant KRAS that constitutively activates the Raf-MEK-MAPK pathway conferring resistance to both radiation and chemotherapy. MEK inhibitors have shown promising anti-tumor responses in recent preclinical and clinical studies, and ar...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Cycle
Egile Nagusiak: Estrada-Bernal, Adriana, Chatterjee, Moumita, Haque, S Jaharul, Yang, Linlin, Morgan, Meredith A, Kotian, Shweta, Morrell, David, Chakravarti, Arnab, Williams, Terence M
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2015
Gaiak:
Report
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825728/
https://ncbi.nlm.nih.gov/pubmed/26505547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1104437
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