Skp2 is required for Aurora B activation in cell mitosis and spindle checkpoint

The Aurora B kinase plays a critical role in cell mitosis and spindle checkpoint. Here, we showed that the ubiquitin E3-ligase protein Skp2, also as a cell-cycle regulatory protein, was required for the activation of Aurora B and its downstream protein. When we restored Skp2 knockdown Hela cells wit...

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Veröffentlicht in:Cell Cycle
Hauptverfasser: Wu, Juan, Huang, Yu-Fan, Zhou, Xin-Ke, Zhang, Wei, Lian, Yi-Fan, Lv, Xiao-Bin, Gao, Xiu-Rong, Lin, Hui-Kuan, Zeng, Yi-Xin, Huang, Jian-Qing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825700/
https://ncbi.nlm.nih.gov/pubmed/26697838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1120916
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