Replication-induced DNA damage after PARP inhibition causes G(2) delay, and cell line-dependent apoptosis, necrosis and multinucleation

PARP inhibitors have been approved for treatment of tumors with mutations in or loss of BRCA1/2. The molecular mechanisms and particularly the cellular phenotypes resulting in synthetic lethality are not well understood and varying clinical responses have been observed. We have investigated the dose...

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Bibliografiska uppgifter
I publikationen:Cell Cycle
Huvudupphovsmän: Dale Rein, Idun, Solberg Landsverk, Kirsti, Micci, Francesca, Patzke, Sebastian, Stokke, Trond
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2015
Ämnen:
Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825575/
https://ncbi.nlm.nih.gov/pubmed/26312527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1085137
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