Differential effects of the NMDA receptor antagonist MK-801 on dopamine receptor D1- and D2-induced abnormal involuntary movements in a preclinical model

Dopamine-replacement therapy with L-DOPA is still the gold standard treatment for Parkinson’s disease. One drawback is the common development of L-DOPA-induced dyskinesia (LID) in patients, which can be as disabling as the disease itself. There is no satisfactory adjunct therapy available. Glutamate...

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Publicat a:Neurosci Lett
Autors principals: Flores, Andrew J., Bartlett, Mitchell J., So, Lisa Y., Laude, Nicholas D., Parent, Kate L., Heien, Michael L., Sherman, Scott J., Falk, Torsten
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825183/
https://ncbi.nlm.nih.gov/pubmed/24525249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2014.02.004
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