The Pleckstrin Homology Domain of Diacylglycerol Kinase η Strongly and Selectively Binds to Phosphatidylinositol 4,5-Bisphosphate

Type II diacylglycerol kinase (DGK) isozymes (δ, η, and κ) have a pleckstrin homology domain (PH) at their N termini. Here, we investigated the lipid binding properties of the PHs of type II DGK isozymes using protein-lipid overlay and liposome binding assays. The PH of DGKη showed the most pronounc...

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發表在:J Biol Chem
Main Authors: Kume, Aiko, Kawase, Koki, Komenoi, Suguru, Usuki, Takako, Takeshita, Ena, Sakai, Hiromichi, Sakane, Fumio
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2016
主題:
Signal Transduction
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825017/
https://ncbi.nlm.nih.gov/pubmed/26887948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.648717
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