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Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis

The KEAP1/Nrf2 pathway senses and responds to changes in intracellular oxidative stress. Mutations that result in constitutive activation of Nrf2 are present in several human tumors, especially non-small cell lung cancer. Therefore, compounds that inhibit Nrf2 activity might be beneficial in treatin...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Mol Cell Proteomics
Main Authors: Vartanian, Steffan, Ma, Taylur P., Lee, James, Haverty, Peter M., Kirkpatrick, Donald S., Yu, Kebing, Stokoe, David
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Biochemistry and Molecular Biology 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4824851/
https://ncbi.nlm.nih.gov/pubmed/26711467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M115.055509
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