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Troglitazone suppresses glutamine metabolism through a PPAR-independent mechanism
Enhanced glutamine metabolism is required for tumor cell growth and survival, which suggests that agents targeting glutaminolysis may have utility within anti-cancer therapies. Troglitazone, a PPARγ agonist, exhibits significant anti-tumor activity and can alter glutamine metabolism in multiple cell...
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| Publicado no: | Biol Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4824301/ https://ncbi.nlm.nih.gov/pubmed/25872876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/hsz-2014-0307 |
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