A Multi-Enzymatic Cascade Reaction for the Stereoselective Production of γ-Oxyfunctionalyzed Amino Acids

A stereoselective three-enzyme cascade for synthesis of diasteromerically pure γ-oxyfunctionalized α-amino acids was developed. By coupling a dynamic kinetic resolution (DKR) using an N-acylamino acid racemase (NAAAR) and an L-selective aminoacylase from Geobacillus thermoglucosidasius with a stereo...

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Bibliographic Details
Published in:Front Microbiol
Main Authors: Enoki, Junichi, Meisborn, Jaqueline, Müller, Ann-Christin, Kourist, Robert
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2016
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823265/
https://ncbi.nlm.nih.gov/pubmed/27092111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2016.00425
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