C. elegans S6K Mutants Require a Creatine Kinase-Like Effector for Lifespan Extension

Deficiency of S6 kinase (S6K) extends the lifespan of multiple species, but the underlying mechanisms are unclear. To discover potential effectors of S6K-mediated longevity, we performed a proteomics analysis of long-lived rsks-1/S6K C. elegans mutants compared to wild-type animals. We identified th...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: McQuary, Philip R., Liao, Chen-Yu, Chang, Jessica T., Kumsta, Caroline, She, Xingyu, Davis, Andrew, Chu, Chu-Chiao, Gelino, Sara, Gomez-Amaro, Rafael L., Petrascheck, Michael, Brill, Laurence M., Ladiges, Warren C., Kennedy, Brian K., Hansen, Malene
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823261/
https://ncbi.nlm.nih.gov/pubmed/26923601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.02.012
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