Metronomic topotecan impedes tumor growth of MYCN-amplified neuroblastoma cells in vitro and in vivo by therapy induced senescence

Poor prognosis and frequent relapses are major challenges for patients with high-risk neuroblastoma (NB), especially when tumors show MYCN amplification. High-dose chemotherapy triggers apoptosis, necrosis and senescence, a cellular stress response leading to permanent proliferative arrest and a typ...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Taschner-Mandl, Sabine, Schwarz, Magdalena, Blaha, Johanna, Kauer, Maximilian, Kromp, Florian, Frank, Nelli, Rifatbegovic, Fikret, Weiss, Tamara, Ladenstein, Ruth, Hohenegger, Martin, Ambros, Inge M., Ambros, Peter F.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823128/
https://ncbi.nlm.nih.gov/pubmed/26657295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6527
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