Inhibition of hypoxia inducible factor 1 and topoisomerase with acriflavine sensitizes perihilar cholangiocarcinomas to photodynamic therapy

Background: Photodynamic therapy (PDT) induces tumor cell death by oxidative stress and hypoxia but also survival signaling through activation of hypoxia-inducible factor 1 (HIF-1). Since perihilar cholangiocarcinomas are relatively recalcitrant to PDT, the aims were to (1) determine the expression...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Weijer, Ruud, Broekgaarden, Mans, Krekorian, Massis, Alles, Lindy K., van Wijk, Albert C., Mackaaij, Claire, Verheij, Joanne, van der Wal, Allard C., van Gulik, Thomas M., Storm, Gert, Heger, Michal
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4823110/
https://ncbi.nlm.nih.gov/pubmed/26657503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6490
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