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XModeScore: a novel method for accurate protonation/tautomer-state determination using quantum-mechanically driven macromolecular X-ray crystallographic refinement

Gaining an understanding of the protein–ligand complex structure along with the proper protonation and explicit solvent effects can be important in obtaining meaningful results in structure-guided drug discovery and structure-based drug discovery. Unfortunately, protonation and tautomerism are diffi...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Acta Crystallogr D Struct Biol
Main Authors: Borbulevych, Oleg, Martin, Roger I., Tickle, Ian J., Westerhoff, Lance M.
פורמט: Artigo
שפה:Inglês
יצא לאור: International Union of Crystallography 2016
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822566/
https://ncbi.nlm.nih.gov/pubmed/27050137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798316002837
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