Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1

BACKGROUND & AIMS: Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells characterised by the invariant TCR-chain, Vα7.2-Jα33, and are restricted by MR1, which presents bacterial vitamin B metabolites. They are important for antibacterial immunity at mucosal sites; however, detaile...

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Detalhes bibliográficos
Publicado no:J Hepatol
Main Authors: Jeffery, Hannah C., van Wilgenburg, Bonnie, Kurioka, Ayako, Parekh, Krishan, Stirling, Kathryn, Roberts, Sheree, Dutton, Emma E., Hunter, Stuart, Geh, Daniel, Braitch, Manjit K., Rajanayagam, Jeremy, Iqbal, Tariq, Pinkney, Thomas, Brown, Rachel, Withers, David R., Adams, David H., Klenerman, Paul, Oo, Ye H.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822535/
https://ncbi.nlm.nih.gov/pubmed/26743076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2015.12.017
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