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Determination of critical nucleation number for a single nucleation amyloid-β aggregation model

Aggregates of amyloid-β (Aβ) peptide are known to be the key pathological agents in Alzheimer disease (AD). Aβ aggregates to form large, insoluble fibrils that deposit as senile plaques in AD brains. The process of aggregation is nucleation–dependent in which the formation of a nucleus is the rate–l...

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Publicat a:Math Biosci
Autors principals: Ghosh, Preetam, Vaidya, Ashwin, Kumar, Amit, Rangachari, Vijayaraghavan
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822416/
https://ncbi.nlm.nih.gov/pubmed/26774039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mbs.2015.12.004
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