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Reconciling the Solution and X-ray Structures of the Villin Headpiece Helical Subdomain: Molecular Dynamics Simulations and Double Mutant Cycles Reveal a Stabilizing Cation-Pi Interaction
The 36 residue helical subdomain of the villin headpiece, HP36, is one of the smallest cooperatively folded proteins, folding on the microsecond timescale. The domain is an extraordinarily popular model system for both experimental and computational studies of protein folding. The structure of HP36...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4822197/ https://ncbi.nlm.nih.gov/pubmed/17338549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061785+ |
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