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The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury
AIMS: During ischemia/reperfusion (I/R), ribosomal S6 kinase (RSK) activates Na(+)/H(+) exchanger 1 (NHE1) by phosphorylating NHE1 at serine 703 (pS703-NHE1), which promotes cardiomyocyte death and injury. Pharmacologic inhibition of NHE1 effectively protects animal hearts from I/R. However, clinica...
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| Publicado no: | J Cardiovasc Pharmacol Ther |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4822162/ https://ncbi.nlm.nih.gov/pubmed/26130615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1074248415591700 |
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