mTORC1 and CK2 coordinate ternary and eIF4F complex assembly

Ternary complex (TC) and eIF4F complex assembly are the two major rate-limiting steps in translation initiation regulated by eIF2α phosphorylation and the mTOR/4E-BP pathway, respectively. How TC and eIF4F assembly are coordinated, however, remains largely unknown. We show that mTOR suppresses trans...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Gandin, Valentina, Masvidal, Laia, Cargnello, Marie, Gyenis, Laszlo, McLaughlan, Shannon, Cai, Yutian, Tenkerian, Clara, Morita, Masahiro, Balanathan, Preetika, Jean-Jean, Olivier, Stambolic, Vuk, Trost, Matthias, Furic, Luc, Larose, Louise, Koromilas, Antonis E., Asano, Katsura, Litchfield, David, Larsson, Ola, Topisirovic, Ivan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822005/
https://ncbi.nlm.nih.gov/pubmed/27040916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11127
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