The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores

The spindle- and kinetochore-associated (Ska) complex is essential for normal anaphase onset in mitosis. The C-terminal domain (CTD) of Ska1 binds microtubules and was proposed to facilitate kinetochore movement on depolymerizing spindle microtubules. Here, we show that Ska complex recruits protein...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Sivakumar, Sushama, Janczyk, Paweł Ł, Qu, Qianhui, Brautigam, Chad A, Stukenberg, P Todd, Yu, Hongtao, Gorbsky, Gary J
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2016
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821802/
https://ncbi.nlm.nih.gov/pubmed/26981768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12902
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