Genomic Aberrations in Crizotinib Resistant Lung Adenocarcinoma Samples Identified by Transcriptome Sequencing

ALK-break positive non-small cell lung cancer (NSCLC) patients initially respond to crizotinib, but resistance occurs inevitably. In this study we aimed to identify fusion genes in crizotinib resistant tumor samples. Re-biopsies of three patients were subjected to paired-end RNA sequencing to identi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Saber, Ali, van der Wekken, Anthonie J., Kok, Klaas, Terpstra, M. Martijn, Bosman, Lisette J., Mastik, Mirjam F., Timens, Wim, Schuuring, Ed, Hiltermann, T. Jeroen N., Groen, Harry J. M., van den Berg, Anke
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821611/
https://ncbi.nlm.nih.gov/pubmed/27045755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153065
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