Enteric Neuronal Damage, Intramuscular Denervation and Smooth Muscle Phenotype Changes as Mechanisms of Chagasic Megacolon: Evidence from a Long-Term Murine Model of Tripanosoma cruzi Infection

We developed a novel murine model of long-term infection with Trypanosoma cruzi with the aim to elucidate the pathogenesis of megacolon and the associated adaptive and neuromuscular intestinal disorders. Our intent was to produce a chronic stage of the disease since the early treatment should avoid...

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Veröffentlicht in:PLoS One
Hauptverfasser: Campos, Camila França, Cangussú, Silvia Dantas, Duz, Ana Luiza Cassin, Cartelle, Christiane Teixeira, Noviello, Maria de Lourdes, Veloso, Vanja Maria, Bahia, Maria Terezinha, Almeida-Leite, Camila Megale, Arantes, Rosa Maria Esteves
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821538/
https://ncbi.nlm.nih.gov/pubmed/27045678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153038
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