ABCB5-targeted chemoresistance reversal inhibits Merkel cell carcinoma growth

Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer with profound but poorly understood resistance to chemotherapy, which poses a significant barrier to clinical MCC treatment. Here we show that ATP–binding cassette member B5 (ABCB5) confers resistance to standard-of-care M...

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Udgivet i:J Invest Dermatol
Main Authors: Kleffel, Sonja, Lee, Nayoung, Lezcano, Cecilia, Wilson, Brian J., Sobolewski, Kristine, Saab, Karim R., Mueller, Hansgeorg, Zhan, Qian, Posch, Christian, Elco, Christopher P., DoRosario, Andrew, Garcia, Sarah S., Thakuria, Manisha, Wang, Yaoyu E., Wang, Linda C., Murphy, George F., Frank, Markus H., Schatton, Tobias
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4821468/
https://ncbi.nlm.nih.gov/pubmed/26827764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2015.12.038
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