Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways

AIM: We have shown that rutaecarpine extracted from the dried fruit of Chinese herb Evodia rutaecarpa (Juss) Benth (Wu Zhu Yu) promotes glucose consumption and anti-inflammatory cytokine expression in insulin-resistant primary skeletal muscle cells. In this study we investigated whether rutaecarpine...

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Bibliographische Detailangaben
Veröffentlicht in:Acta Pharmacol Sin
Hauptverfasser: Nie, Xu-qiang, Chen, Huai-hong, Zhang, Jian-yong, Zhang, Yu-jing, Yang, Jian-wen, Pan, Hui-jun, Song, Wen-xia, Murad, Ferid, He, Yu-qi, Bian, Ka
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820804/
https://ncbi.nlm.nih.gov/pubmed/26972495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.167
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