Adh enhances Actinobacillus pleuropneumoniae pathogenicity by binding to OR5M11 and activating p38 which induces apoptosis of PAMs and IL-8 release

Members of the Trimeric Autotransporter Adhesin (TAA) family play a crucial role in the adhesion of Gram-negative pathogens to host cells, but the immunopathogenesis of TAAs remains unknown. Our previous studies demonstrated that Adh from Actinobacillus pleuropneumoniae (A. pleuropneumoniae) is requ...

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Udgivet i:Sci Rep
Main Authors: Wang, Lei, Qin, Wanhai, Zhang, Jing, Bao, Chuntong, Zhang, Hu, Che, Yanyi, Sun, Changjiang, Gu, Jingmin, Feng, Xin, Du, Chongtao, Han, Wenyu, Richard, Paul Langford, Lei, Liancheng
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820727/
https://ncbi.nlm.nih.gov/pubmed/27046446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24058
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