The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy

The heart responds to pathological overload through myocyte hypertrophy. Here we show that this response is regulated by cardiac fibroblasts via a paracrine mechanism involving plasma membrane calcium ATPase 4 (PMCA4). Pmca4 deletion in mice, both systemically and specifically in fibroblasts, reduce...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Mohamed, Tamer M. A., Abou-Leisa, Riham, Stafford, Nicholas, Maqsood, Arfa, Zi, Min, Prehar, Sukhpal, Baudoin-Stanley, Florence, Wang, Xin, Neyses, Ludwig, Cartwright, Elizabeth J., Oceandy, Delvac
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820544/
https://ncbi.nlm.nih.gov/pubmed/27020607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11074
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