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Deuterated Protein Folds Obtained Directly from Unassigned NOE Data

We demonstrate the feasibility of determining the global fold of a highly deuterated protein from unassigned experimental NMR nuclear Overhauser effect (NOE) data only. The method relies on the calculation of a spatial configuration of covalently unconnected protons—a “cloud”—directly from unassigne...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Bermejo, Guillermo A., Llinás, Miguel
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819401/
https://ncbi.nlm.nih.gov/pubmed/18318535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja074836e
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