Naïve-pooled pharmacokinetic analysis of pyrazinamide, isoniazid and rifampicin in plasma and cerebrospinal fluid of Vietnamese children with tuberculous meningitis

BACKGROUND: Among the various forms of TB, tuberculous meningitis (TBM) is the most severe, with about 30 % mortality and 50 % of survivors left with neurological sequelae. Children suffer more frequently from TBM than adults and outcomes are often poor due to difficulties in making the diagnosis an...

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Veröffentlicht in:BMC Infect Dis
Hauptverfasser: Pouplin, Thomas, Bang, Nguyen Duc, Toi, Pham Van, Phuong, Pham Nguyen, Dung, Nguyen Huy, Duong, Tran Ngoc, Caws, Maxine, Thwaites, Guy E., Tarning, Joel, Day, Jeremy N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818938/
https://ncbi.nlm.nih.gov/pubmed/27039088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12879-016-1470-x
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