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Signalling beyond photon absorption: extracellular retinoids and growth factors modulate rod photoreceptor sensitivity

KEY POINTS: We propose that the end product of chromophore bleaching in rod photoreceptors, all‐trans retinol, is part of a feedback loop that increases the sensitivity of the phototransduction cascade in rods. A previously described light‐induced hypersensitivity in rods, termed adaptive potentiati...

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Bibliographic Details
Published in:J Physiol
Main Authors: McKeown, Alex S., Pitale, Priyamvada M., Kraft, Timothy W.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818600/
https://ncbi.nlm.nih.gov/pubmed/26691896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271650
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