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Pre‐emptive analgesia and its supraspinal mechanisms: enhanced descending inhibition and decreased descending facilitation by dexmedetomidine

KEY POINTS: Despite the clinical importance of pre‐emptive analgesia, the mechanisms by which it attenuates pain associated with central sensitization are poorly understood. We find that fentanyl and the α2‐adrenoceptor agonist dexmedetomidine (Dex) differ significantly in their modulatory actions o...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: You, Hao‐Jun, Lei, Jing, Xiao, Ying, Ye, Gang, Sun, Zhi‐Hong, Yang, Lan, Niu, Nan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818597/
https://ncbi.nlm.nih.gov/pubmed/26732231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271991
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