Hmga2 is necessary for Otx2-dependent exit of embryonic stem cells from the pluripotent ground state

BACKGROUND: A crucial event in the differentiation of mouse embryonic stem cells (ESCs) is the exit from the pluripotent ground state that leads to the acquisition of the ‘primed’ pluripotent phenotype, characteristic of the epiblast-like stem cells (EpiLCs). The transcription factors Oct4 and Otx2...

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Veröffentlicht in:BMC Biol
Hauptverfasser: Navarra, Angelica, Musto, Anna, Gargiulo, Anna, Petrosino, Giuseppe, Pierantoni, Giovanna Maria, Fusco, Alfredo, Russo, Tommaso, Parisi, Silvia
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818510/
https://ncbi.nlm.nih.gov/pubmed/27036552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-016-0246-5
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