Peroxisome Proliferator–Activated Receptor α Protects Renal Tubular Cells from Gentamicin-Induced Apoptosis via Upregulating Na(+)/H(+) Exchanger NHE1

Peroxisome proliferator–activated receptor (PPAR)-α is a transcription factor that has been reported to inhibit gentamicin-induced apoptosis in renal tubular cells. However, the antiapoptotic mechanism of PPARα is still unknown. In this study, we found that PPARα overexpression induced Na(+)/H(+) ex...

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Udgivet i:Mol Med
Main Authors: Chen, Cheng-Hsien, Chen, Tso-Hsiao, Wu, Mei-Yi, Chen, Jia-Rung, Hong, Li-Yu, Zheng, Cai-Mei, Chiu, I-Jen, Lin, Yuh-Feng, Hsu, Yung-Ho
Format: Artigo
Sprog:Inglês
Udgivet: The Feinstein Institute Press 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818255/
https://ncbi.nlm.nih.gov/pubmed/26623927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2015.00196
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