A Lentiviral Vector Allowing Physiologically Regulated Membrane-anchored and Secreted Antibody Expression Depending on B-cell Maturation Status

The development of lentiviral vectors (LVs) for expression of a specific antibody can be achieved through the transduction of mature B-cells. This approach would provide a versatile tool for active immunotherapy strategies for infectious diseases or cancer, as well as for protein engineering. Here,...

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Publicat a:Mol Ther
Autors principals: Fusil, Floriane, Calattini, Sara, Amirache, Fouzia, Mancip, Jimmy, Costa, Caroline, Robbins, Justin B, Douam, Florian, Lavillette, Dimitri, Law, Mansun, Defrance, Thierry, Verhoeyen, Els, Cosset, François-Loïc
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817946/
https://ncbi.nlm.nih.gov/pubmed/26281898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.148
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