Neurogenic Niche Microglia Undergo Positional Remodeling and Progressive Activation Contributing to Age-Associated Reductions in Neurogenesis

Neural stem cells (NSCs) exist throughout life in the ventricular–subventricular zone (V-SVZ) of the mammalian forebrain. During aging NSC function is diminished through an unclear mechanism. In this study, we establish microglia, the immune cells of the brain, as integral niche cells within the V-S...

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Detalhes bibliográficos
Publicado no:Stem Cells Dev
Main Authors: Solano Fonseca, Rene, Mahesula, Swetha, Apple, Deana M., Raghunathan, Rekha, Dugan, Allison, Cardona, Astrid, O'Connor, Jason, Kokovay, Erzsebet
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2016
Assuntos:
Original Research Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817564/
https://ncbi.nlm.nih.gov/pubmed/26857912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2015.0319
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