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Structural Studies of Lipopolysaccharide-defective Mutants from Brucella melitensis Identify a Core Oligosaccharide Critical in Virulence

The structures of the lipooligosaccharides from Brucella melitensis mutants affected in the WbkD and ManB(core) proteins have been fully characterized using NMR spectroscopy. The results revealed that disruption of wbkD gives rise to a rough lipopolysaccharide (R-LPS) with a complete core structure...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Fontana, Carolina, Conde-Álvarez, Raquel, Ståhle, Jonas, Holst, Otto, Iriarte, Maite, Zhao, Yun, Arce-Gorvel, Vilma, Hanniffy, Seán, Gorvel, Jean-Pierre, Moriyón, Ignacio, Widmalm, Göran
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817197/
https://ncbi.nlm.nih.gov/pubmed/26867577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.701540
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