Novel KCNJ10 Gene Variations Compromise Function of Inwardly Rectifying Potassium Channel 4.1

The KCNJ10 gene encoding Kir4.1 contains numerous SNPs whose molecular effects remain unknown. We investigated the functional consequences of uncharacterized SNPs (Q212R, L166Q, and G83V) on homomeric (Kir4.1) and heteromeric (Kir4.1-Kir5.1) channel function. We compared these with previously charac...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Méndez-González, Miguel P., Kucheryavykh, Yuriy V., Zayas-Santiago, Astrid, Vélez-Carrasco, Wanda, Maldonado-Martínez, Gerónimo, Cubano, Luis A., Nichols, Colin G., Skatchkov, Serguei N., Eaton, Misty J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817196/
https://ncbi.nlm.nih.gov/pubmed/26867573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.679910
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